The hormone-binding unit of luteinizing hormone receptor
نویسندگان
چکیده
منابع مشابه
NMR Studies of Metal-binding Luteinizing Hormone Releasing Hormone
Functions of the luteinizing hormone releasing hormone (LHRH) and its induced release by divalent metal ions have received great attention because this neurotransmitter subsequently regulates the secretion of luteinizing hormone (LH). Metal-LHRH complexes were synthesized by addition of various Cu(II),Ni(II),Zn(II) ions into LHRH in order to understand how the induced release of LHRH is possibl...
متن کاملAssociation of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome
BACKGROUND High circulating luteinizing hormone (LH) level is a typical biochemical feature of polycystic ovary syndrome (PCOS) whose pathophysiology is still unclear. Certain mutations of LH and LH receptor (LHR) may lead to changes in bioactivity of these hormones. The aim of this study was determine the role of the LH and LHR polymorphisms in the pathogenesis of PCOS using a genetic approach...
متن کاملLuteinizing hormone receptors: specific binding of human luteinizing hormone to homogenates of luteinized rat ovaries.
Binding of human [(125)I]luteinizing hormone to homogenates of luteinized rat ovaries is dependent upon time, temperature, and pH and is saturable. Injection of human chorionic gonadotropin in vivo or addition of unlabeled human chorionic gonadotropin or human or ovine luteinizing hormone in vitro inhibits binding, whereas follicle stimulating hormone or prolactin is without effect. The dissoci...
متن کاملLuteinizing hormone-releasing hormone antagonists.
BACKGROUND Luteinizing hormone-releasing hormone (LH-RH) plays a central role in the vertebrate reproduction by regulating gonadal activity. Based on its binding to pituitary LH-RH receptors, as well as to LH-RH receptors expressed on cancer cells, LH-RH agonists and antagonists have been developed for different therapeutic applications. OBJECTIVE/METHOD Here we give an overview of the most r...
متن کاملP-228: Altered Expression of Folliclestimulating Hormone Receptor and Luteinizing Hormone Receptor in Granulosa Cells from Women with Polycystic Ovary Syndrome
Background: Polycystic ovary syndrome (PCOS) is a common complex genetic endocrinopathy, affecting 5 - 10% of women at reproductive age. PCO granulosa cells seem to have abnormal responses to follicle- stimulating hormone (FSH). FSH is considered to be a pituitary glycoprotein that plays an important role during folliculogenesis as it promotes the proliferation and differentiation of granulosa ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1982
ISSN: 0306-3283
DOI: 10.1042/bj2080309